Bridging the gap between the clinical laboratory and medical management by relating pathophysiology to analytical results in health and disease, this classic resource provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Its up-to-date, encyclopedic coverage of the field defines analytical criteria for the medical usefulness of laboratory procedures, introduces new approaches for establishing reference ranges, describes variables that affect tests and results, examines modern analytical tools and their impact on lab management and costs, and demonstrates the applications of statistical methods.
Contents: Section 1 Laboratory Principles 1. Introduction to Principles of Laboratory Analyses and Safety 2. Specimen Collection and Processing Section 2 Analytical Techniques and Instrumentation 3. Optical Techniques 4. Electrochemistry and Chemical Sensors 5. Electrophoresis 6. Chromatography 7. Mass Spectometry 8. Principles of Clinical Enzymology 9. Principles of Immunochemical Techniques 10. Nanotechnology and Microfabrication 11. Automation in the Clinical Laboratory 12. Point-of-Care Testing Section 3 Principles of Laboratory Medicine 13. Introduction to Laboratory Medicine and Evidence-Based Laboratory Medicine 14. Selection and Analytical Evaluation of Methods- with Statistical Techniques 15. Clinical Evaluation of Methods 16. Establishment and Use of Reference Values 17. Preanalytical Variables and Biological Variation 18. Clinical Laboratory Informatics 19. Quality Management Section 4 Analytes 20. Amino Acids, Peptides, and Proteins 21. Enzymes 22. Cytokines 23. Tumor Markers 24. Kidney Function Tests 25. Carbohydrates 26. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors 27. Electrolytes and Blood Gases 28. Hormones 29. Catecholamines and Serotonin 30. Vitamins and Trace Elements 31. Hemoglobin, Iron, and Bilirubin 32. Porphyrins and Disorders of Porphyrin Metabolism 33. Therapeutic Drugs and Their Management 34. Clinical Toxicology 35. Toxic Metals Section 5 Molecular Diagnostics and Genetics 36. Principles of Molecular Biology and Approaches to Nucleic Acid Isolation 37. Nucleic Acid Techniques 38. Design and Operation of the Molecular Diagnostics Laboratory 39. Molecular Genetics and Diagnosis of Hematopoietic Neoplasms 40. Inherited Diseases 41. Identity Assessment 42. Molecular Methods in Diagnosis and Monitoring of Infectious Diseases 43. Pharmacogenetics Section 6 Pathophysiology 44. Cardiac Function 45. Kidney Disease 46. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism 47. Liver Disease 48. Gastric, Pancreatic, and Intestinal Function 49. Mineral and Bone Metabolism 50. Pituitary Function 51. The Adrenal Cortex 52. The Thyroid -Pathophysiology and Thyroid Function Testing 53. Reproductive Related Disorders 54. Clinical Chemistry of Pregnancy 55. Inborn Errors of Amino Acid, Organic Acid, and Fatty Acid Metabolism Section 7 Appendix 56. Reference Information for the Clinical Laboratory